Dual Targeting of DNA Gyrase and Topoisomerase IV: Target Interactions of Heteroaryl Isothiazolones in Staphylococcus aureus

Heteroaryl isothiazolones (HITZs) are antibacterial agents that display excellent in vitro activity against Staphylococcus aureus. We recently identified a series of these compounds that show potent bactericidal activities against methicillin-resistant Staphylococcus aureus (MRSA). We report here th...

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Detalhes bibliográficos
Main Authors: Cheng, Jijun, Thanassi, Jane A., Thoma, Christy L., Bradbury, Barton J., Deshpande, Milind, Pucci, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913236/
https://ncbi.nlm.nih.gov/pubmed/17502409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00158-07
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