Dual Targeting of DNA Gyrase and Topoisomerase IV: Target Interactions of Heteroaryl Isothiazolones in Staphylococcus aureus

Eitemau Tebyg

• In Vitro and In Vivo Antibacterial Activities of Heteroaryl Isothiazolones against Resistant Gram-Positive Pathogens
  gan: Pucci, Michael J., et al.
  Cyhoeddwyd: (2007)
• Selective Targeting of Topoisomerase IV and DNA Gyrase in Staphylococcus aureus: Different Patterns of Quinolone- Induced Inhibition of DNA Synthesis
  gan: Fournier, Bénédicte, et al.
  Cyhoeddwyd: (2000)
• DNA Cleavage Activities of Staphylococcus aureus Gyrase and Topoisomerase IV Stimulated by Quinolones and 2-Pyridones
  gan: Saiki, Anne Y. C., et al.
  Cyhoeddwyd: (1999)
• Quinolone resistance mutations in topoisomerase IV: relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus.
  gan: Ng, E Y, et al.
  Cyhoeddwyd: (1996)
• Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones.
  gan: Pan, X S, et al.
  Cyhoeddwyd: (1997)