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Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53
The transcriptional coactivator p300 binds to and mediates the transcriptional functions of the tetrameric tumor suppressor p53. Both proteins consist of independently folded domains linked by intrinsically disordered sequences. A well studied short sequence of the p53 transactivation domain, p53(15...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2007
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1855428/ https://ncbi.nlm.nih.gov/pubmed/17438265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702010104 |
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