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Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53

The transcriptional coactivator p300 binds to and mediates the transcriptional functions of the tetrameric tumor suppressor p53. Both proteins consist of independently folded domains linked by intrinsically disordered sequences. A well studied short sequence of the p53 transactivation domain, p53(15...

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Bibliografiske detaljer
Main Authors: Teufel, Daniel P., Freund, Stefan M., Bycroft, Mark, Fersht, Alan R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855428/
https://ncbi.nlm.nih.gov/pubmed/17438265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702010104
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