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Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53
The transcriptional coactivator p300 binds to and mediates the transcriptional functions of the tetrameric tumor suppressor p53. Both proteins consist of independently folded domains linked by intrinsically disordered sequences. A well studied short sequence of the p53 transactivation domain, p53(15...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2007
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1855428/ https://ncbi.nlm.nih.gov/pubmed/17438265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702010104 |
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