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Lamin A-Dependent Nuclear Defects in Human Aging

Mutations in the nuclear structural protein lamin A cause the premature aging syndrome Hutchinson-Gilford progeria (HGPS). Whether lamin A plays any role in normal aging is unknown. We show that the same molecular mechanism responsible for HGPS is active in healthy cells. Cell nuclei from old indivi...

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Detalhes bibliográficos
Main Authors: Scaffidi, Paola, Misteli, Tom
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855250/
https://ncbi.nlm.nih.gov/pubmed/16645051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1127168
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