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Lamin A-Dependent Nuclear Defects in Human Aging
Mutations in the nuclear structural protein lamin A cause the premature aging syndrome Hutchinson-Gilford progeria (HGPS). Whether lamin A plays any role in normal aging is unknown. We show that the same molecular mechanism responsible for HGPS is active in healthy cells. Cell nuclei from old indivi...
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| Glavni autori: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2006
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1855250/ https://ncbi.nlm.nih.gov/pubmed/16645051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1127168 |
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