A Novel and Dynamic Mechanism for AKAP Binding to RII Isoforms of cAMP-dependent Protein Kinase

A Kinase Anchoring Proteins (AKAPs) target PKA to specific microdomains using an amphipathic helix that docks to N-terminal Dimerization/Docking (D/D) domains of PKA regulatory (R) subunits. To understand specificity, we solved the crystal structure of the helical motif from d-AKAP2, a dual-specific...

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Autori principali: Kinderman, Francis S., Kim, Choel, von Daake, Sventja, Ma, Yuliang, Pham, Bao Q., Spraggon, Glen, Xuong, Nguyen-Huu, Jennings, Patricia A., Taylor, Susan S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855097/
https://ncbi.nlm.nih.gov/pubmed/17081990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2006.09.015
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