The RBCC Gene RFP2 (Leu5) Encodes a Novel Transmembrane E3 Ubiquitin Ligase Involved in ERAD

RFP2, a gene frequently lost in various malignancies, encodes a protein with RING finger, B-box, and coiled-coil domains that belongs to the RBCC/TRIM family of proteins. Here we demonstrate that Rfp2 is an unstable protein with auto-polyubiquitination activity in vivo and in vitro, implying that Rf...

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Autors principals: Lerner, Mikael, Corcoran, Martin, Cepeda, Diana, Nielsen, Michael L., Zubarev, Roman, Pontén, Fredrik, Uhlén, Mathias, Hober, Sophia, Grandér, Dan, Sangfelt, Olle
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855009/
https://ncbi.nlm.nih.gov/pubmed/17314412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-03-0248
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