Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol

AIM: The effects of 24(S),25-epoxycholesterol (24,25EC) on aspects of cholesterol homeostasis is well-documented. When added to cells, 24,25EC decreases cholesterol synthesis and up-regulates cholesterol efflux genes, including ABCA1. Synthesis of 24,25EC occurs in a shunt of the mevalonate pathway...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Wong, Jenny, Quinn, Carmel M, Brown, Andrew J
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2007
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1854894/
https://ncbi.nlm.nih.gov/pubmed/17408498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-511X-6-10
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