The Oxysterol 24(S),25-Epoxycholesterol Attenuates Human Smooth Muscle–Derived Foam Cell Formation Via Reduced Low-Density Lipoprotein Uptake and Enhanced Cholesterol Efflux

BACKGROUND: Foam cell formation by intimal smooth muscle cells (SMCs) inhibits the elaboration of extracellular matrix, which is detrimental to plaque stabilization. In the present study, we examined the lipoproteins and receptors involved in human SMC foam cell formation and investigated the abilit...

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Detalhes bibliográficos
Main Authors: Beyea, Michael M., Reaume, Samantha, Sawyez, Cynthia G., Edwards, Jane Y., O'Neil, Caroline, Hegele, Robert A, Pickering, J Geoffrey, Huff, Murray W
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487330/
https://ncbi.nlm.nih.gov/pubmed/23130136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.112.000810
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