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PDTM-04. THERAPEUTIC MODULATION OF CHOLESTEROL HOMEOSTASIS IN DIPG THROUGH MASSIVE GENERATION OF 24,25-EPOXYCHOLESTEROL

Diffuse intrinsic pontine glioma (DIPG) remains a uniformly fatal childhood tumor for which novel pharmacological treatments are desperately needed. In recent work, we performed a small molecule screen in a pre-clinical DIPG model, identifying MI-2 as the top ‘hit’, showing anti-tumor activity in vi...

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Podrobná bibliografie
Vydáno v:Neuro Oncol
Hlavní autoři: Phillips, Richard, Smith, Ryan, Funato, Kosuke, Liang, Yupu, Thompson, Bonne, Mitsche, Matthew, Jeffrey, McDonald, Tabar, Viviane, Allis, C David
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217175/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.846
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