Oncogenic K-Ras Signals through Epidermal Growth Factor Receptor and Wild-Type H-Ras to Promote Radiation Survival in Pancreatic and Colorectal Carcinoma Cells

Pancreatic and colorectal carcinomas frequently express oncogenic/mutant K-Ras that contributes to both tumorigenesis and clinically observed resistance to radiation treatment. We have previously shown that farnesyltransferase inhibitors (FTI) radiosensitize many pancreatic and colorectal cancer cel...

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Main Authors: Cengel, Keith A., Voong, K. Rahn, Chandrasekaran, Sanjay, Maggiorella, Laurence, Brunner, Thomas B., Stanbridge, Eric, Kao, Gary D., McKenna, W. Gillies, Bernhard, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1854847/
https://ncbi.nlm.nih.gov/pubmed/17460778
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