Llwytho...

Mutagenesis of non-conserved active site residues improves the activity and narrows the specificity of human thymidine kinase 2

Human thymidine kinase 2 (TK2) is critical for the nucleotide salvage pathway and phosphorylation of nucleoside analog prodrugs in vivo; however, it remains poorly studied because of difficulties expressing it heterologously. TK2 is strictly pyrimidine-specific, whereas its phylogenetic relative, th...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gerth, Monica L., Lutz, Stefan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1853344/
https://ncbi.nlm.nih.gov/pubmed/17266931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2007.01.070
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