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Mutagenesis of non-conserved active site residues improves the activity and narrows the specificity of human thymidine kinase 2
Human thymidine kinase 2 (TK2) is critical for the nucleotide salvage pathway and phosphorylation of nucleoside analog prodrugs in vivo; however, it remains poorly studied because of difficulties expressing it heterologously. TK2 is strictly pyrimidine-specific, whereas its phylogenetic relative, th...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1853344/ https://ncbi.nlm.nih.gov/pubmed/17266931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2007.01.070 |
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