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Combining specificity determining and conserved residues improves functional site prediction

BACKGROUND: Predicting the location of functionally important sites from protein sequence and/or structure is a long-standing problem in computational biology. Most current approaches make use of sequence conservation, assuming that amino acid residues conserved within a protein family are most like...

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Detalhes bibliográficos
Main Authors: Kalinina, Olga V, Gelfand, Mikhail S, Russell, Robert B
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709924/
https://ncbi.nlm.nih.gov/pubmed/19508719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-10-174
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