The high-resolution NMR structure of the R21A Spc-SH3:P41 complex: Understanding the determinants of binding affinity by comparison with Abl-SH3

BACKGROUND: SH3 domains are small protein modules of 60–85 amino acids that bind to short proline-rich sequences with moderate-to-low affinity and specificity. Interactions with SH3 domains play a crucial role in regulation of many cellular processes (some are related to cancer and AIDS) and have th...

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Main Authors: Casares, Salvador, AB, Eiso, Eshuis, Henk, Lopez-Mayorga, Obdulio, van Nuland, Nico AJ, Conejero-Lara, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1853097/
https://ncbi.nlm.nih.gov/pubmed/17407569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-7-22
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