Accurate characterization of weak macromolecular interactions by titration of NMR residual dipolar couplings: application to the CD2AP SH3-C:ubiquitin complex

The description of the interactome represents one of key challenges remaining for structural biology. Physiologically important weak interactions, with dissociation constants above 100 μM, are remarkably common, but remain beyond the reach of most of structural biology. NMR spectroscopy, and in part...

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Hlavní autoři: Ortega-Roldan, Jose Luis, Jensen, Malene Ringkjøbing, Brutscher, Bernhard, Azuaga, Ana I., Blackledge, Martin, van Nuland, Nico A. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2009
Témata:
Methods Online
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685109/
https://ncbi.nlm.nih.gov/pubmed/19359362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp211
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