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Autoinhibition of Bcr-Abl through Its SH3 Domain

Bcr-Abl is a dysregulated tyrosine kinase whose mechanism of activation is unclear. Here, we demonstrate that, like c-Abl, Bcr-Abl is negatively regulated through its SH3 domain. Kinase activity, transformation, and leukemogenesis by Bcr-Abl are greatly impaired by mutations of the Bcr coiled-coil d...

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Bibliografiske detaljer
Udgivet i:Mol Cell
Main Authors: Smith, Kristen M., Yacobi, Rinat, Van Etten, Richard A.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press. Published by Elsevier Inc. 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7128750/
https://ncbi.nlm.nih.gov/pubmed/12887890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1097-2765(03)00274-0
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