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Autoinhibition of Bcr-Abl through Its SH3 Domain
Bcr-Abl is a dysregulated tyrosine kinase whose mechanism of activation is unclear. Here, we demonstrate that, like c-Abl, Bcr-Abl is negatively regulated through its SH3 domain. Kinase activity, transformation, and leukemogenesis by Bcr-Abl are greatly impaired by mutations of the Bcr coiled-coil d...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cell Press. Published by Elsevier Inc.
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7128750/ https://ncbi.nlm.nih.gov/pubmed/12887890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1097-2765(03)00274-0 |
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