Role of p27(Kip1) and Cyclin-Dependent Kinase 2 in the Proliferation of Non-Small Cell Lung Cancer

The cell cycle is governed by a family of cyclin-dependent kinases (Cdks). Cdk2 forms a functional complex with cyclin E and plays a pivotal role in the regulation of G1/S transition. Cdk2 activity is negatively regulated by interactions with inhibitors. p27(Kip1), one of the most potent inhibitors...

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Autori principali: Kawana, Hidetada, Tamaru, Jun-ichi, Tanaka, Tomoaki, Hirai, Aizan, Saito, Yasushi, Kitagawa, Masatoshi, Mikata, Atsuo, Harigaya, Kenichi, Kuriyama, Takayuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 1998
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Regular Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852977/
https://ncbi.nlm.nih.gov/pubmed/9708810
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