Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles

Monoallelic RUNX1 mutations cause familial platelet disorder with predisposition for acute myelogenous leukemia (FPD/AML). Sporadic mono- and biallelic mutations are found at high frequencies in AML M0, in radiation-associated and therapy-related myelodysplastic syndrome and AML, and in isolated cas...

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Main Authors: Matheny, Christina J, Speck, Maren E, Cushing, Patrick R, Zhou, Yunpeng, Corpora, Takeshi, Regan, Michael, Newman, Miki, Roudaia, Liya, Speck, Caroline L, Gu, Ting-Lei, Griffey, Stephen M, Bushweller, John H, Speck, Nancy A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852839/
https://ncbi.nlm.nih.gov/pubmed/17290219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601568
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