Evidence for the Location of the Allosteric Activation Switch in the Multisubunit Phosphorylase Kinase Complex from Mass Spectrometric Identification of Chemically Crosslinked Peptides

Phosphorylase kinase (PhK), an (αβγδ)(4) complex, regulates glycogenolysis. Its activity, catalyzed by the γ subunit, is tightly controlled by phosphorylation and activators acting through allosteric sites on its regulatory α, β and δ subunits. Activation of the catalytic γ subunit in the PhK comple...

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Hlavní autoři: Nadeau, Owen W., Anderson, David W., Yang, Qing, Artigues, Antonio, Paschall, Justin E., Wyckoff, Gerald J., McClintock, Jennifer L., Carlson, Gerald M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852525/
https://ncbi.nlm.nih.gov/pubmed/17123541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.10.061
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