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A model for activation of the hexadecameric phosphorylase kinase complex deduced from zero‐length oxidative crosslinking

Phosphorylase kinase (PhK) is a hexadecameric (αβγδ)(4) enzyme complex that upon activation by phosphorylation stimulates glycogenolysis. Due to its large size (1.3 MDa), elucidating the structural changes associated with the activation of PhK has been challenging, although phosphoactivation has bee...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Thompson, Jackie A., Nadeau, Owen W., Carlson, Gerald M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815228/
https://ncbi.nlm.nih.gov/pubmed/26362516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2804
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