Evidence for the Location of the Allosteric Activation Switch in the Multisubunit Phosphorylase Kinase Complex from Mass Spectrometric Identification of Chemically Crosslinked Peptides

Phosphorylase kinase (PhK), an (αβγδ)(4) complex, regulates glycogenolysis. Its activity, catalyzed by the γ subunit, is tightly controlled by phosphorylation and activators acting through allosteric sites on its regulatory α, β and δ subunits. Activation of the catalytic γ subunit in the PhK comple...

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Bibliographic Details
Main Authors: Nadeau, Owen W., Anderson, David W., Yang, Qing, Artigues, Antonio, Paschall, Justin E., Wyckoff, Gerald J., McClintock, Jennifer L., Carlson, Gerald M.
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852525/
https://ncbi.nlm.nih.gov/pubmed/17123541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.10.061
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