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Reduction of GVHD and enhanced antitumor effects after adoptive infusion of alloreactive Ly49-mismatched NK cells from MHC-matched donors

We investigated if an infusion of alloreactive natural killer (NK) cells would reduce GVHD and mediate antitumor effects in mice undergoing MHC-matched allogeneic stem cell transplantation (SCT). Balb/c mice bearing RENCA tumors underwent an allogeneic SCT from MHC-matched B10.d2 donors and were giv...

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Autori principali: Lundqvist, Andreas, Philip McCoy, J., Samsel, Leigh, Childs, Richard
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852249/
https://ncbi.nlm.nih.gov/pubmed/17179231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-05-024315
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