טוען...
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
The mTOR complex 2 (mTORC2) containing mTOR and rictor is thought to be rapamycin insensitive and was recently shown to regulate the prosurvival kinase AKT by phosphorylation on Ser473. We investigated the molecular effects of mTOR inhibition by the rapamycin derivatives (RDs) temsirolimus (CCI-779)...
שמור ב:
| Main Authors: | , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society of Hematology
2007
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1852241/ https://ncbi.nlm.nih.gov/pubmed/17179228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-06-030833 |
| תגים: |
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