Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML

The mTOR complex 2 (mTORC2) containing mTOR and rictor is thought to be rapamycin insensitive and was recently shown to regulate the prosurvival kinase AKT by phosphorylation on Ser473. We investigated the molecular effects of mTOR inhibition by the rapamycin derivatives (RDs) temsirolimus (CCI-779)...

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Detalhes bibliográficos
Main Authors: Zeng, Zhihong, Sarbassov, Dos D., Samudio, Ismael J., Yee, Karen W. L., Munsell, Mark F., Ellen Jackson, C., Giles, Francis J., Sabatini, David M., Andreeff, Michael, Konopleva, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852241/
https://ncbi.nlm.nih.gov/pubmed/17179228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-06-030833
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