Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins

Two classes of sterols, cholesterol and oxysterols, block export of sterol regulatory element-binding proteins (SREBPs) from the endoplasmic reticulum (ER) to the Golgi by preventing the binding of COPII-coated proteins to a hexapeptide sorting signal (MELADL) in Scap, the SREBP-escort protein. Here...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Sun, Li-Ping, Seemann, Joachim, Goldstein, Joseph L., Brown, Michael S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Feature Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851663/
https://ncbi.nlm.nih.gov/pubmed/17428919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700907104
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky