Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins

Two classes of sterols, cholesterol and oxysterols, block export of sterol regulatory element-binding proteins (SREBPs) from the endoplasmic reticulum (ER) to the Golgi by preventing the binding of COPII-coated proteins to a hexapeptide sorting signal (MELADL) in Scap, the SREBP-escort protein. Here...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Sun, Li-Ping, Seemann, Joachim, Goldstein, Joseph L., Brown, Michael S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Feature Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851663/
https://ncbi.nlm.nih.gov/pubmed/17428919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700907104
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge