Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals

Development of invariant natural killer T (iNKT) cells requires the presentation of lipid ligand(s) by CD1d molecules in the thymus. The glycosphingolipid (GSL) isoglobotrihexosylceramide (iGb3) has been proposed as the natural iNKT cell-selecting ligand in the thymus and to be involved in periphera...

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Autors principals: Speak, Anneliese O., Salio, Mariolina, Neville, David C. A., Fontaine, Josette, Priestman, David A., Platt, Nick, Heare, Tanya, Butters, Terry D., Dwek, Raymond A., Trottein, Francois, Exley, Mark A., Cerundolo, Vincenzo, Platt, Frances M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851601/
https://ncbi.nlm.nih.gov/pubmed/17372214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607285104
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