Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals

Development of invariant natural killer T (iNKT) cells requires the presentation of lipid ligand(s) by CD1d molecules in the thymus. The glycosphingolipid (GSL) isoglobotrihexosylceramide (iGb3) has been proposed as the natural iNKT cell-selecting ligand in the thymus and to be involved in periphera...

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Bibliographic Details
Main Authors: Speak, Anneliese O., Salio, Mariolina, Neville, David C. A., Fontaine, Josette, Priestman, David A., Platt, Nick, Heare, Tanya, Butters, Terry D., Dwek, Raymond A., Trottein, Francois, Exley, Mark A., Cerundolo, Vincenzo, Platt, Frances M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851601/
https://ncbi.nlm.nih.gov/pubmed/17372214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607285104
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