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Simultaneous amino acid substitutions at antigenic sites drive influenza A hemagglutinin evolution

The HA1 domain of HA, the major antigenic protein of influenza A viruses, contains all of the antigenic sites of HA and is under continual immune-driven selection. To resolve controversies on whether only a few or many residue sites of HA1 have undergone positive selection, whether positive selectio...

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Bibliografiske detaljer
Main Authors: Shih, Arthur Chun-Chieh, Hsiao, Tzu-Chang, Ho, Mei-Shang, Li, Wen-Hsiung
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851070/
https://ncbi.nlm.nih.gov/pubmed/17395716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701396104
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