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Accumulation of Amino Acid Substitutions Promotes Irreversible Structural Changes in the Hemagglutinin of Human Influenza AH3 Virus during Evolution

In order to clarify the effect of an accumulation of amino acid substitutions on the hemadsorption character of the influenza AH3 virus hemagglutinin (HA) protein, we introduced single-point amino acid changes into the HA1 domain of the HA proteins of influenza viruses isolated in 1968 (A/Aichi/2/68...

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Bibliografiske detaljer
Main Authors: Nakajima, Katsuhisa, Nobusawa, Eri, Nagy, Alexander, Nakajima, Setsuko
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1091720/
https://ncbi.nlm.nih.gov/pubmed/15858030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.10.6472-6477.2005
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