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Restriction of Amino Acid Change in Influenza A Virus H3HA: Comparison of Amino Acid Changes Observed in Nature and In Vitro

We introduced 248 single-point amino acid changes into hemagglutinin (HA) protein of the A/Aichi/2/68 (H3N2) strain by a PCR random mutation method. These changes were classified as positive or negative according to their effect on hemadsorption activity. We observed following results. (i) The perce...

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Bibliografiske detaljer
Main Authors: Nakajima, Katsuhisa, Nobusawa, Eri, Tonegawa, Ken, Nakajima, Setsuko
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC224596/
https://ncbi.nlm.nih.gov/pubmed/12941919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.18.10088-10098.2003
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