Identification of Low- and High-Impact Hemagglutinin Amino Acid Substitutions That Drive Antigenic Drift of Influenza A(H1N1) Viruses

Determining phenotype from genetic data is a fundamental challenge. Identification of emerging antigenic variants among circulating influenza viruses is critical to the vaccine virus selection process, with vaccine effectiveness maximized when constituents are antigenically similar to circulating vi...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Harvey, William T., Benton, Donald J., Gregory, Victoria, Hall, James P. J., Daniels, Rodney S., Bedford, Trevor, Haydon, Daniel T., Hay, Alan J., McCauley, John W., Reeve, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825936/
https://ncbi.nlm.nih.gov/pubmed/27057693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005526
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