Mania-like behavior induced by disruption of CLOCK

Circadian rhythms and the genes that make up the molecular clock have long been implicated in bipolar disorder. Genetic evidence in bipolar patients suggests that the central transcriptional activator of molecular rhythms, CLOCK, may be particularly important. However, the exact role of this gene in...

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Detalhes bibliográficos
Main Authors: Roybal, Kole, Theobold, David, Graham, Ami, DiNieri, Jennifer A., Russo, Scott J., Krishnan, Vaishnav, Chakravarty, Sumana, Peevey, Joseph, Oehrlein, Nathan, Birnbaum, Shari, Vitaterna, Martha H., Orsulak, Paul, Takahashi, Joseph S., Nestler, Eric J., Carlezon, William A., McClung, Colleen A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851061/
https://ncbi.nlm.nih.gov/pubmed/17379666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609625104
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