Knock-down of CLOCK in the VTA through RNAi results in a mixed state of mania and depression-like behavior

BACKGROUND: Circadian rhythm abnormalities are strongly associated with bipolar disorder, however the role of circadian genes in mood regulation is unclear. Previously, we reported that mice with a mutation in the Clock gene (ClockΔ19) display a behavioral profile that is strikingly similar to bipol...

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Detalhes bibliográficos
Main Authors: Mukherjee, Shibani, Coque, Laurent, Cao, Jun-Li, Kumar, Jaswinder, Chakravarty, Sumana, Asaithamby, Aroumougame, Graham, Ami, Gordon, Elizabeth, Enwright, John F., DiLeone, Ralph J., Birnbaum, Shari G., Cooper, Donald C., McClung, Colleen A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929276/
https://ncbi.nlm.nih.gov/pubmed/20591414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2010.04.031
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