Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

Mad2 is an essential component of the spindle checkpoint that blocks activation of separase and dissolution of sister chromatids until microtubule attachment to kinetochores is complete. We show here that overexpression of Mad2 in transgenic mice leads to a wide variety of neoplasias, appearance of...

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Main Authors: Sotillo, Rocío, Hernando, Eva, Díaz-Rodríguez, Elena, Teruya-Feldstein, Julie, Cordón-Cardo, Carlos, Lowe, Scott W., Benezra, Robert
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850996/
https://ncbi.nlm.nih.gov/pubmed/17189715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2006.10.019
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