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Mad2 overexpression promotes aneuploidy and tumorigenesis in mice
Mad2 is an essential component of the spindle checkpoint that blocks activation of separase and dissolution of sister chromatids until microtubule attachment to kinetochores is complete. We show here that overexpression of Mad2 in transgenic mice leads to a wide variety of neoplasias, appearance of...
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| Main Authors: | , , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2006
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1850996/ https://ncbi.nlm.nih.gov/pubmed/17189715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2006.10.019 |
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