Overexpression of Separase induces aneuploidy and mammary tumorigenesis

Separase is an endopeptidase that separates sister chromatids by cleaving cohesin Rad21 during the metaphase-to-anaphase transition. Conditional expression of Separase in tetracycline-inducible diploid FSK3 mouse mammary epithelial cells with both p53 WT and mutant (Ser-233-234) alleles of unknown p...

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Detalhes bibliográficos
Main Authors: Zhang, Nenggang, Ge, Gouquing, Meyer, Rene, Sethi, Sumita, Basu, Dipanjan, Pradhan, Subhashree, Zhao, Yi-Jue, Li, Xiao-Nan, Cai, Wei-Wen, El-Naggar, Adel K., Baladandayuthapani, Veerabhadran, Kittrell, Frances S., Rao, Pulivarthi H., Medina, Daniel, Pati, Debananda
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529090/
https://ncbi.nlm.nih.gov/pubmed/18728194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801610105
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