Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice

BACKGROUND: Cohesin protease Separase plays a key role in faithful segregation of sister chromatids by cleaving the cohesin complex at the metaphase to anaphase transition. Homozygous deletion of ESPL1 gene that encodes Separase protein results in embryonic lethality in mice and Separase overexpress...

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Autori principali: Mukherjee, Malini, Ge, Gouqing, Zhang, Nenggang, Huang, Eryong, Nakamura, Lanelle V., Minor, Marissa, Fofanov, Viacheslav, Rao, Pullivarthi H., Herron, Alan, Pati, Debananda
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143119/
https://ncbi.nlm.nih.gov/pubmed/21799785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022167
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