Stable β-Secretase Activity and Presynaptic Cholinergic Markers During Progressive Central Nervous System Amyloidogenesis in Tg2576 Mice

We examined presynaptic cholinergic markers and β-secretase activity during progressive central nervous system amyloidogenesis in Tg2576 Alzheimer mice (transgenic for human amyloid precursor protein Swedish mutation; hAPPswe). At 14, 18, and 23 months of age there were no significant differences be...

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Autores principales: Gau, Jen-Tzer, Steinhilb, Michelle L., Kao, Tzu-Cheg, D’Amato, Constance J., Gaut, James R., Frey, Kirk A., Turner, R. Scott
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2002
Materias:
Animal Models
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850661/
https://ncbi.nlm.nih.gov/pubmed/11839594
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