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Immunization with a Nontoxic/Nonfibrillar Amyloid-β Homologous Peptide Reduces Alzheimer’s Disease-Associated Pathology in Transgenic Mice

Transgenic mice with brain amyloid-β (Aβ) plaques immunized with aggregated Aβ1-42 have reduced cerebral amyloid burden. However, the use of Aβ1-42 in humans may not be appropriate because it crosses the blood brain barrier, forms toxic fibrils, and can seed fibril formation. We report that immuniza...

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Main Authors: Sigurdsson, Einar M., Scholtzova, Henrieta, Mehta, Pankaj D., Frangione, Blas, Wisniewski, Thomas
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2001
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850561/
https://ncbi.nlm.nih.gov/pubmed/11485902
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