Altered Trafficking of Membrane Proteins in Purkinje Cells of SCA1 Transgenic Mice

Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease caused by the expression of mutant ataxin-1 that contains an expanded polyglutamine tract. Overexpression of mutant ataxin-1 in Purkinje cells of transgenic mice results in a progressive ataxia and Purkinje cell pathology that are v...

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Bibliographic Details
Main Authors: Skinner, Pamela J., Vierra-Green, Cynthia A., Clark, H. Brent, Zoghbi, Huda Y., Orr, Harry T.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2001
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850456/
https://ncbi.nlm.nih.gov/pubmed/11549583
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