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Expression of Heparanase in Normal, Dysplastic, and Neoplastic Human Colonic Mucosa and Stroma : Evidence for Its Role in Colonic Tumorigenesis

The human heparanase gene, an endo-β-glucuronidase that cleaves heparan sulfate at specific intrachain sites, has recently been cloned and shown to function in tumor progression and metastatic spread. Antisense digoxigenin-labeled heparanase RNA probe and monoclonal anti-human heparanase antibodies...

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Hlavní autoři: Friedmann, Yael, Vlodavsky, Israel, Aingorn, Helena, Aviv, Ayelet, Peretz, Tuvia, Pecker, Iris, Pappo, Orit
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2000
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850180/
https://ncbi.nlm.nih.gov/pubmed/11021821
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