Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis

The present study emphasizes the importance of cell surface expression and secretion of heparanase (endo-β-d-glucuronidase) in tumor angiogenesis and metastasis. For this purpose, nonmetastatic Eb mouse lymphoma cells were transfected with the predominantly intracellular human heparanase or with a r...

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Main Authors: Goldshmidt, Orit, Zcharia, Eyal, Abramovitch, Rinat, Metzger, Shula, Aingorn, Helena, Friedmann, Yael, Schirrmacher, Volker, Mitrani, Eduardo, Vlodavsky, Israel
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2002
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC126619/
https://ncbi.nlm.nih.gov/pubmed/12097647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.152070599
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