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Expression of Heparanase in Normal, Dysplastic, and Neoplastic Human Colonic Mucosa and Stroma : Evidence for Its Role in Colonic Tumorigenesis
The human heparanase gene, an endo-β-glucuronidase that cleaves heparan sulfate at specific intrachain sites, has recently been cloned and shown to function in tumor progression and metastatic spread. Antisense digoxigenin-labeled heparanase RNA probe and monoclonal anti-human heparanase antibodies...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Investigative Pathology
2000
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1850180/ https://ncbi.nlm.nih.gov/pubmed/11021821 |
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