Induction of granzyme B and T cell cytotoxic capacity by IL-2 or IL-15 without antigens: Multiclonal responses that are extremely lytic if triggered and short-lived after cytokine withdrawal.

The purpose of these studies was to determine the minimal requirements to induce granzyme B, cytotoxic granules and perforin-dependent lytic capacity. To our surprise, both IL-2 and IL-15 induced not only proliferation, but also profound granzyme B and lytic capacity from CD8(+) T cells in the absen...

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Hlavní autoři: Tamang, David L., Redelman, Doug, Alves, Bryce N., Vollger, Leanne, Bethley, Christy, Hudig, Dorothy
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850105/
https://ncbi.nlm.nih.gov/pubmed/17188506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cyto.2006.11.008
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