Inhibition of p38α MAPK rescues cardiomyopathy induced by overexpressed β(2)-adrenergic receptor, but not β(1)-adrenergic receptor

We examined the role of p38α MAPK in mediating cardiomyopathy in mice overexpressing β(1)-adrenergic receptor (β(1)-AR) or β(2)-AR by mating them with dominant-negative p38α (DNp38α) MAPK mice. Both β(1)-AR and β(2)-AR Tg mice had enhanced LV ejection fraction (LVEF) as young adults and developed si...

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Autors principals: Peter, Pallavi S., Brady, Jennifer E., Yan, Lin, Chen, Wei, Engelhardt, Stefan, Wang, Yibin, Sadoshima, Junichi, Vatner, Stephen F., Vatner, Dorothy E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2007
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1849986/
https://ncbi.nlm.nih.gov/pubmed/17446930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29576
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