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The structural determinants of checkpoint activation
Here, we demonstrate that primed, single-stranded DNA (ssDNA) is sufficient for activation of the ATR-dependent checkpoint pathway in Xenopus egg extracts. Using this structure, we define the contribution of the 5′- and 3′-primer ends to Chk1 activation when replication is blocked and ongoing. In ad...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cold Spring Harbor Laboratory Press
2007
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1847708/ https://ncbi.nlm.nih.gov/pubmed/17437996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1522607 |
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