The structural determinants of checkpoint activation

Here, we demonstrate that primed, single-stranded DNA (ssDNA) is sufficient for activation of the ATR-dependent checkpoint pathway in Xenopus egg extracts. Using this structure, we define the contribution of the 5′- and 3′-primer ends to Chk1 activation when replication is blocked and ongoing. In ad...

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Autori principali: MacDougall, Christina A., Byun, Tony S., Van, Christopher, Yee, Muh-ching, Cimprich, Karlene A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2007
Soggetti:
Research Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1847708/
https://ncbi.nlm.nih.gov/pubmed/17437996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1522607
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