Reduced expression of mitochondrial frataxin in mice exacerbates diet-induced obesity

Published evidence suggests that adiposity in humans may be linked to impaired energy expenditure for reasons widely unresolved. We have generated mice with a systemic impairment of oxidative phosphorylation (OXPHOS) due to aP2 cre-mediated targeted disruption, and unexpectedly ubiquitous reduction...

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Bibliographic Details
Main Authors: Pomplun, Doreen, Voigt, Anja, Schulz, Tim J., Thierbach, René, Pfeiffer, Andreas F., Ristow, Michael
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1847459/
https://ncbi.nlm.nih.gov/pubmed/17404227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611631104
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