Frataxin deficiency in pancreatic islets causes diabetes due to loss of β cell mass

Diabetes is caused by an absolute (type 1) or relative (type 2) deficiency of insulin-producing β cells. We have disrupted expression of the mitochondrial protein frataxin selectively in pancreatic β cells. Mice were born healthy but subsequently developed impaired glucose tolerance progressing to o...

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Detalhes bibliográficos
Main Authors: Ristow, Michael, Mulder, Hindrik, Pomplun, Doreen, Schulz, Tim J., Müller-Schmehl, Katrin, Krause, Anja, Fex, Malin, Puccio, Hélène, Müller, Jörg, Isken, Frank, Spranger, Joachim, Müller-Wieland, Dirk, Magnuson, Mark A., Möhlig, Matthias, Koenig, Michel, Pfeiffer, Andreas F.H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC171391/
https://ncbi.nlm.nih.gov/pubmed/12925693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200318107
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