Variable Expression of Cre Recombinase Transgenes Precludes Reliable Prediction of Tissue-Specific Gene Disruption by Tail-Biopsy Genotyping

The Cre/loxP-system has become the system of choice for the generation of conditional so-called knockout mouse strains, i.e. the tissue-specific disruption of expression of a certain target gene. We here report the loss of expression of Cre recombinase in a transgenic mouse strain with increasing nu...

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Bibliographic Details
Main Authors: Schulz, Tim J., Glaubitz, Markus, Kuhlow, Doreen, Thierbach, René, Birringer, Marc, Steinberg, Pablo, Pfeiffer, Andreas F. H., Ristow, Michael
Format: Artigo
Language:Inglês
Published: Public Library of Science 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1995755/
https://ncbi.nlm.nih.gov/pubmed/17925861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001013
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